Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
This position is full-time and works approximately 40 hours per week.
Department Name/Job Location:
This position is in the Department of Pediatrics Rheumatology. This position is for the Medical School Campus.
A postdoctoral fellow position is available in the laboratory of Anthony French to study dysregulated innate immunity in pediatric patients with immunodeficiencies and autoimmunity. The French laboratory is particularly interested in delineating innate immune defects in patients with unusually severe and/or recurrent herpesvirus infections and innate immune signaling defects in pediatric patients with autoimmune disorders such as juvenile dermatomyositis (JDM) and systemic juvenile idiopathic arthritis (sJIA).
Using cutting edge, high dimensional techniques including mass cytometry (CyTOF), RNA-seq, and whole exome sequencing, the laboratory has a number of patients at different stages of evaluation. The laboratory recently published a manuscript (Throm et al., JCI Insight 2018) describing defects in phospholipase C-gamma 2 (PLCG2) signaling in NK cells in 17 treatment na�ve JDM patients compared to 17 healthy pediatric controls which manifests in decreased NK cell calcium flux. This position would build on ongoing studies in the laboratory to understand the mechanistic underpinnings and functional implications of the dysregulation of PLCG2 phosphorylation in these JDM patients, with the goal of developing strategies to mitigate the impact of this innate immune signaling defect in JDM patients.
PhD, MD, or equivalent terminal doctoral degree.
Candidates should have experience in immunology as well as cellular and molecular biology.
The applicant should possess strong written and oral communication skills as well as demonstrated ability to implement laboratory protocols, independently conduct and interpret research experiments, and document research findings.
The candidate should be highly motivated, creative, and be able to work both independently and within a team.
Experience with tissue culture, flow cytometry, and cellular functional assays would be beneficial.
Familiarity with basic statistical analysis and R is desirable.
Base pay commensurate with experience.
This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Applicant Special Instructions:
Applicants should send a cover letter including a description of their career goals, a paragraph on their prior research experience, curriculum vitae, and the names and contact information for 3 references to Dr. Anthony French (email@example.com).
Laboratory environment with potential exposure to biological and chemical hazards including human biospecimens (e.g., blood).
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.