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Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
This position is full-time and works approximately 40 hours per week.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Rheumatology. This position is for the Medical School Campus.
The laboratory of Dr. Chyi-Song Hsieh has an opening for a post-doctoral fellow to study antigen specific host immune system interactions with gut commensal bacteria. We have been interested in understanding how certain microbes induce tolerance via differentiation of na�ve T cells into peripheral regulatory T cells (Lathrop et al, Nature, 2011) and how this process may be affected by an inflammatory environment (Chai et al, Sci. Immunol., 2017). One of our primary goals is to understand the cellular and molecular mechanisms that control T cell interactions with gut bacteria. Other projects include understanding the effect of stress or infection on host-commensal interactions, as well as understanding the development of the antigen specific gut immune system early in life.
T cell differentiation to self-antigen
Relationship between microbiota and the differentiation of Foxp3+ regulatory T cells
Stress and the mucosal immune response
Analysis of neonatal T cell immune response
Perry, J.S.A., Russler-Germain, E.V., Zhou, Y.W., Purtha, W., Cooper, M.L., Choi, J., Schroeder, M.A., Salazar, V., Egawa, T., Lee, B.C., Abumrad, N.A., Kim, B.S., Anderson, M.S., Dipersio, J.F., Hsieh, C.S. (2018). Transfer of cell-surface antigens by scavenger receptor CD36 promotes thymic regulatory T cell receptor repertoire development and allo-tolerance. Immunity, 48, 923-936. PMCID: PMC5986080.
Chai JN, Peng Y, Rengarajan S, Solomon BD, Ai TL, Shen Z, Perry JSA, Knoop KA, Tanoue T, Narushima S, Honda K, Elson CO, Newberry RD, Stappenbeck TS, Kau AL, Peterson DA, Fox JG, Hsieh CS. Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation (2017). Sci. Immunol. 2:pii: eaal5068
Nustch K, Chai JN, Ai TL, Russler-Germain E, Feehley T, Nagler CR, Hsieh CS (2016). Rapid and efficient generation of regulatory T cells to commensal antigens in the periphery. Cell Reports, 17, 206-20. PMCID: PMC5051580
Lathrop, S.K., Bloom, S.M., Rao, S.M., Nutsch, K., Lio, C.W., Santacruz, N., Peterson, D.A., Stappenbeck, T.S., & Hsieh, C.S. (2011). Peripheral education of the immune system by colonic commensal microbiota. Nature, 478, 250-4. PMCID: PMC3192908
Candidates with prior experience in cellular or molecular immunology or microbiology with a recent Ph.D. or M.D. degree are encouraged to apply. Working with mice is a requirement.
Prior experience with flow cytometry.
Mammalian cell culture experience.
Microbiology skills, including anaerobic culture.
Ability to handle mice and perform injections.
Experience with analysis of high throughput sequencing such as RNA-Seq, 16S, and TCR repertoire.
Independent and motivated individual.
Base pay commensurate with experience.
This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Applicant Special Instructions:
Applicants should submit curriculum vitae and 2-3 references (upon request) to firstname.lastname@example.org.
Dr. Chyi-Song Hsieh
Division of Rheumatology, School of Medicine
Washington University in St. Louis
St. Louis, MO
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
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